UNIVERSIDAD DE CHILE – FACULTAD DE MEDICINA

INSTITUTO DE CIENCIAS BIOMEDICAS

PROGRAMA DE ANATOMIA Y BIOLOGIA DEL DESARROLLO

CURRICULUM VITAE

NOMBRE: LUIS DAVID LEMUS ACUÑA

LUGAR DE TRABAJO     :LABORATORIO DE EMBRIOLOGIA EXPERIMENTAL Y MOLECULAR, DEPARTAMENTO DE ANATOMIA Y BIOLOGIA DEL DESARROLLO, INSTITUTO DE CIENCIAS BIOMEDICAS,                  FACULTAD DE MEDICINA,  UNIVERSIDAD DE CHILE,                                              CHILE.

POSICION EN LA ORGANIZACIÓN: FULL PROFESOR, DIRECTOR DEL DEPARTAMENTO DE                ANATOMIA Y BIOLOGIA DEL DESARROLLO

PRINCIPALES PUBLICACIONES:

Garrido O, Letelier R, Rosas C, Fuenzalida M, Ferreira A, Lemus D. Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3. Biol Res 43:3, 317 – 322, 2010.

Toledo V, Ramirez G, Valck C, Lopez N, Ribeiro C, Maldonado I, Aguilar L, Lemus D, Ferreira A. Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens. Biol Res 43:3, 287 – 289, 2010.

López NC, Valck C, Ramírez G, Rodríguez M, Ribeiro C, Orellana J, Maldonado I, Albini A, Anacona D, Lemus D, Aguilar L, Schwaeble W, Ferreira A. Antiangiogenic and antitumor effects of Trypanosoma cruzi Calreticulin. PLoS Negl Trop Dis. 2010 Jul 6;4(7):e730. PubMed PMID: 20625551; PubMed Central PMCID: PMC2897838.

 Ferreira V, Molina MC, Schwaeble W, Lemus D, Ferreira A. Does Tripanosoma cruzi calreticulin modulate the complement system and angiogenesis? Trenes Parasitol. 2005 Apr;21(4):169-74. Review. PubMed PMID: 15780838.

Molina MC, Ferreira V, Valck C, Aguilar L, Orellana J, Rojas A, Ramirez G, Billetta R, Schwaeble W, Lemus D, Ferreira A. An in vivo role for Tripanosoma cruzi calreticulin in antiangiogenesis. Mol Biochem Parasitol. 2005

Apr;140(2):133-40. Epub 2005 Jan 26. PubMed PMID: 15760653.

 Fuenzalida M, Lemus S, Illanes J, Montiel E, Acuña O, Lemus D. Histochemical detection of sugar residues in lizard teeth (Liolaemus gravenhorsti): a lectin-binding study. Biol Res. 2000;33(3-4):215-26. PubMed PMID: 15696682.

Zúñiga J, Fuenzalida M, Guerrero A, Illanes J, Dabancens A, Díaz E, Lemus D. Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. Biol Res. 2003;36(2):233-40. PubMed PMID: 14513718.

Illanes J, Dabancens A, Acuña O, Fuenzalida M, Guerrero A, Lopez C, Lemus D. Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse. Biol Res. 2002;35(3-4):339-45. PubMed PMID: 12462986.

Strauss L, Fuenzalida M, Illanes J, Dabancens A, Díaz E, Lemus D, Guerrero A. Effect of sulfated beta-cyclodextrin, a water soluble cycloamylose, on the promotion and/or inhibition of angiogenesis. Pathol Oncol Res. 2002;8(1):47-53. PubMed PMID: 11994763.

 Lemus D, Dabancens A, Illanes J, Fuenzalida M, Guerrero A, López C. Antiangiogenic effect of betamethasone on the chick cam stimulated by TA3 tumor supernatant. Biol Res. 2001;34(3-4):227-36. PubMed PMID: 11715860.

 Illanes J, Fuenzalida M, Romero S, González P, Lemus D. Ethanol effect on the chick embryo ossification: a macroscopic and microscopic study. Biol Res. 1999;32(2-3):77-84. PubMed PMID: 10883321.

Fuenzalida M, Illanes J, Lemus R, Guerrero A, Oyarzún A, Acuña O, Lemus D. Microscopic and histochemical study of odontoclasts in physiologic resorption of teeth of the polyphyodont lizard, Liolaemus gravenhorsti. J Morphol. 1999 Dec;242(3):295-309. PubMed PMID: 10580267.

Wacyk J, Fuenzalida M, Morales M, Acuña O, Lemus D. Effect of cholinergic agonists on muscular tonus of the lizard small intestine and esophagus. Biol Res. 1999;32(1):29-33. PubMed PMID: 10530339.

 Lemus D, Lemus R, Romero S, Arancibia N, Fuenzalida M. Detection of sugar residues in rabbit embryo teeth with lectin-horseradish peroxidase conjugate: II. A light microscopal study. J Morphol. 1997 Feb;231(2):175-84. PubMed PMID: 8989874.

 Lemus D, Romero S, Lemus R, Garcia J, Fuenzalida M. Light microscopic detection of sugar residues in rabbit embryo teeth with lectin-horseradish peroxidase conjugates. J Morphol. 1996 Feb;227(2):185-95. PubMed PMID: 8568907.

 Lemus D. Contributions of heterospecific tissue recombinations to odontogenesis. Int J Dev Biol. 1995 Feb;39(1):291-7. Review. PubMed PMID:7626419.

 Fuenzalida M, Lemus R, Romero S, Fernandez-Valencia R, Lemus D. Behavior of rabbit dental tissues in heterospecific association with embryonic quail ectoderm. J Exp Zool. 1990 Dec;256(3):264-72. PubMed PMID: 2250161.

 Montenegro MA, Rojas MA, Lemus D, González E, Blánquez MJ. [Involution of the tooth germ in sheep (Ovis aries)]. Anat Histol Embryol. 1989 Dec;18(4):297-304. Spanish. PubMed PMID: 2624321.

Lemus D, Coloma L, Fuenzalida M, Illanes J, Paz de la Vega Y, Ondarza A, Blanquez MJ. Odontogenesis and amelogenesis in interacting lizard-quail tissue combinations. J Morphol. 1986 Aug;189(2):121-9. PubMed PMID: 3746915.

 Paz de la Vega Y, Villalobos M, Lemus D, Acosta R. [Effect of biogenic amines (histamine and 5-hydroxytryptamine) on the motility and the muscles of the digestive tract of iguana (Liolaemus gravenhorsti, Reptila-Squamata-Iguanidae)]. Zentralbl Veterinarmed A. 1986 Jan;33(1):73-8. Spanish. PubMed PMID: 3085392.

Av. Independencia 1027, casilla 70079 correo 7 Santiago-CHILE - Fono: 56–2 – 6786262-6785 –  Fax: 56–2 -  678 6264

e-mail: dlemus@med.uchile.cl